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Objective: To explore the pathogen composition and distribution characteristics of pathogens in respiratory samples from patients with fever of unknown origin. Methods: A total of 96 respiratory samples of patients with unknown cause fever with respiratory symptoms were collected from four hospitals above grade II in Shijiazhuang area (Hebei Provincial Hospital of Traditional Chinese Medicine, Luancheng District People's Hospital, Luquan District People's Hospital, Shenze County Hospital) from January to April 2020, and multiplex-fluorescent polymerase chain reaction(PCR)was used to detect influenza A virus, influenza B virus, enterovirus, parainfluenza virus I/II/III/IV, respiratory adenovirus, human metapneumovirus, respiratory syncytial virus, human rhinovirus, human bocavirus, COVID-19, Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Streptococcus pneumoniae, Klebsiella pneumoniae, Group A streptococcus, Haemophilus influenzae, Staphylococcus aureus nucleic acid detection, the results were analyzed for chi-square. Results: A total of 8 pathogens were detected in the upper respiratory tract samples of 96 fever patients, including 1 kind of virus, 6 kinds of bacterias, and Mycoplasma pneumoniae. There were 12 viruses including influenza virus and parainfluenza virus, Legionella pneumophila and Chlamydia pneumoniae were not detected. The pathogen detection rates in descending order were Streptococcus pneumoniae (58/96, 60.42%), Haemophilus influenzae(38/96, 39.58%), Klebsiella pneumoniae (14/96, 14.58%), Staphylococcus aureus (10/96, 10.42%), Mycoplasma pneumoniae (8/96, 8.33%), Pseudomonas aeruginosa (6/96, 6.25%), Group A streptococcus (4/96, 4.17%) and human rhinovirus (2/96, 2.08%). The proportions of single-pathogen infection and multi-pathogen mixed infection in fever clinic patients were similar, 41.67% (40/96) and 45.83% (44/96), respectively, and 12.50% (12/96)of the cases had no pathogens detected. The infection rate of Mycoplasma pneumoniae in female patients with fever (21.43%) was higher than that in male patients with fever (2.94%) (P < 0.05). There was no statistical difference between the distribution of of other pathogens and gender and age(P > 0.05). Conclusions: The upper respiratory tract pathogens were mainly bacterial infections, and occasional human rhinovirus and Mycoplasma pneumonia infections. In clinical diagnosis and treatment, comprehensive consideration should be given to the pathogen detection.
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Objective: To investigate the relationship between negative attentional bias and post-traumatic stress disorder(PTSD) in the context of higher depression and anxiety symptoms after the outbreak of COVID-19, so as to provide scientific basis for mental health education in primary and secondary schools. Methods: From March to April 2021, a total of 708 students from primary school and junior high school (grade 6 through grade 9) in Beijing, Shanxi, Hunan, Shandong, Hebei, Hubei of China were selected. The Children's Revised Impact of Event Scale(CRIES), the Attention to Positive and Negative Information Scale (APNI)and Depression, Anxiety and Stress Scale-21(DASS-21) were used in a questionnaire survey. Results: A total of 242 students were diagnosed with PTSD, and the detection rate was 34.2%. The scores of intrusion and high arousal of boys(7.92+or-5.33, 8.60+or-5.41) were lower than those of girls(8.72+or-4.85, 9.50+or-4.76), and the difference was statistically significant (t=-2.04, -2.32, P < 0.05). There were statistically significant differences of negative attention bias, CRIES score, intrusion, debarb and high arousal among primary and middle school students of different grades (F=3.57, 5.99, 4.45, 4.60, 7.40, P < 0.05). Negative attention bias, anxiety, depression and post-traumatic stress symptoms were significantly positively correlated (r=0.27-0.84, P < 0.05). Logistic regression analysis showed that anxiety (OR=1.13, 95%CI=1.06-1.20) and negative attention bias (OR=1.10, 95%CI=1.07-1.12) were positively associated with PTSD symptoms in primary and middle school students(P < 0.01). Conclusion: Anxiety and depressive symptoms show impacts on negative attention bias and might exacerbate the symptoms of post-traumatic stress disorder. Therefore, emotional adjustments can help reduce the post-traumatic stress response in the post-epidemic period.
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Objective: Vaccines are one of the promising approaches to control the pandemic. The aim of this study, which was conducted on healthcare workers who previously were or were not infected with COVID-19, was to evaluate the undesirable effects that developed after the CoronaVac (Sinovac Life Sciences, Beijing, China). Methods: Volunteers who were administered the first dose of inactivated CoronaVac vaccine between January 14-24, 2021, were included in this retrospective study. Demographic information was obtained from the questionnaire results and from the data of the applications made due to side effects. Results: 911 healthcare workers, 232 of whom had a history of COVID-19 were included in the study. The mean age of those with a history of COVID-19, was 36 (20-66), and 33.6% were men. 26.7% were doctors, 34.9% were nurses, 155 (66.8%) worked in internal and 62 (26.7%) in surgical units. There was no significant difference between the two groups regarding age, gender, task, and the departments they worked in. Comorbidities were present in 25.9% of the group with a history of COVID-19;the most common disease was asthma (5.6%). Allergy history was 4.3% in the group with COVID-19 and 7.8% in the other group (p=0.070). The incidence of post-vaccine adverse events (62.9%) was higher in those with a history of COVID-19 than in those without (57.1%). The most common adverse event was a headache, and it was significantly higher in the group who had COVID-19 compared to those who had not (36.6% vs. 27.7%;p=0.01). Conclusion: In our study, we observed that the rates of undesirable effects after vaccination were high in individuals with a history of COVID-19. Although it is thought that this situation may be related to the developing antibody response rates, the insufficient number of cases and the lack of determination of the antibody response after infection and vaccination are a disadvantage of the study.
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Purpose: Based on text content analysis using big data, this study aims to explore differences in guest perceptions of peer-to-peer accommodations before and after COVID-19 to provide suggestions for the development of these properties in China postpandemic. Design/methodology/approach: A guest perception dictionary was established by collecting Ctrip customer reviews of peer-to-peer accommodations. After data cleaning, thematic word analysis and semantic association network analysis were used to explore perceptions and thematic differences before and after COVID-19. Findings: This research constructed a multidimensional framework of guest-perceived values for peer-to-peer accommodation in the context of COVID-19. The findings showed that the emphasis on functionality in peer-to-peer accommodation changed;perceived emotional values associated with peer-to-peer stays were more complex;perceived social values decreased, host-guest interactions were reduced and online communication became a stronger trend;tourist preferences for types of experiences changed, and people changed their destination selections;perceived conditional value was reflected in perceived risks, and the perceptions of environmental health, service and physical risks increased. Research limitations/implications: This research has constructed a multidimensional framework of tourist perceived value on the basis of peer-to-peer accommodation context and epidemic background and has thus shown the changes in tourist perceived value of peer-to-peer accommodation before and after COVID-19. Originality/value: To the best of authors' knowledge, this research constitutes the first attempt to explore the perceptual differences for peer-to-peer accommodations before and after COVID-19 based on an extensive data set of online reviews from multiple provinces of China.
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Purpose: COVID-19 affects the peer-to-peer (P2P) accommodation industry. With regard to prospect theory, individuals' negative emotions, such as institutional distrust, are easily evoked and impede consumption intention in an environment of permeating uncertainty and risks. While existing research indicates the negative effects of institutional distrust, scant research has explored its antecedents and intervention mechanisms. This study thus aims to unveil the influencing factors and explore mitigating mechanisms of customers' institutional distrust of P2P accommodations. Design/methodology/approach: Online reviews data were used to identify the underlying critical issues. The authors developed a model to depict how institutional distrust is formed under the boundary condition of subjective norm by the results. The model was verified using a questionnaire survey. Finally, in-depth semi-structured interviews were conducted to ensure its robustness. Findings: The external environment and internal platform effectiveness are two critical aspects affecting institutional distrust of P2P accommodations. The external environment influences institutional distrust through perceived threat, explaining the formation mechanism of customers' institutional distrust through customers' internal psychology. Furthermore, the authors found subjective norm moderating the effect of perceived threat on customers' institutional distrust. Research limitations/implications: This is one of the first studies, to the best of the authors' knowledge, to explore institutional distrust of P2P accommodations after COVID-19. The finding contributes to studies on P2P accommodation by uncovering the contingent role of subjective norm in influencing customers' institutional distrust. Originality/value: This is a pioneering study that explores the antecedents and mitigating mechanisms of institutional distrust of P2P accommodations during the new normal of COVID-19.
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In order to perform the isolation of avian infectious bronchitis virus (IBV) and study the pathogenicity of IBV isolate, the RT-PCR was used to detect nucleic acid extracted from a clinical sample of chickens, which were suspected to be infected with infectious bronchitis virus (IBV) and provided by a farmer in Yuncheng, Shanxi province. And the sample was detected as IBV positive by RT-PCR. Then 9-11-day-old SPF chicken embryonated eggs were inoculated with the sample filtered from the grinding fluid, and the obtained allantoic fluid was blindly passed by three generations (F3) and was also tested as IBV positive;The F11 generation passaged in embryonated eggs caused typical "dwarf embryo" lesions to SPF chicken embryonated eggs, and induced the loss of cilia in tracheal rings. The results showed that an IBV strain was isolated and named as YC181031. The S1 gene amplification and sequencing analysis showed that YC181031 strain belonged to IBV GI-22 genotype, which is also nephropathogenic type IBV. Seven-day-old SPF chicks were used to test the pathogenicity of the isolate. The results showed that several clinical symptoms were showed in chicks infected with YC181031, such as breathing with difficulty, depression, excreting watery droppings and death. The mortality of infected chicks was 20%. Typical pathological changes such as enlargement of kidney and urate deposition in the kidney were observed in infected chicks. The immunohistochemical assay and viral load detection were performed for the tissue samples from infected and dead chicks. The tissue lesions and distribution of virus were observed in the kidney, trachea, lung, glandular stomach, spleen and liver samples of infected chicks. RT-PCR detection of pharyngeal anal swabs showed that the virus shedding by infected chicks could be continuously detected within 14 days of the test period;The viral loads of various tissues were detected by RT-qPCR and the results showed that the viral load from high to low was kidney, trachea, lung, stomach, spleen and liver. The viral load of kidney was significantly higher than that of other tissues (P < 0.05).In this study, the pathogenicity characteristics of GI-22 genotype strain were systematically studied for the first time, providing a reference for the prevention and treatment of the disease.
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Objective: To analyze the changes in incidence of notifiable infectious diseases in Jiading district of Shanghai in the context of COVID-19 epidemic. Methods: The incidence data of notifiable infectious disease in Jiading during 2017-2021 were collected for the comparison of the incidence rates before and after the implementation of COVID-19 prevention and control measures. Results: The incidence rate of notifiable infectious diseases in Jiading was 167.59/100000 in 2020, 60.20% lower than the average level during 2017-2019 (421.04/100000) (X2=2424.369, P < 0.001)and the incidence rate was 213.82/100000 in 2021, 49.22% lower than the average level during 2017-2019 (X2=1 578.996, P < 0.001). The incidence of class B and C infectious diseases in 2020 and 2021 were lower than the average incidence during 2017-2019, and the incidence of class B infectious diseases decreased by 38.79% in 2020 and 30.70% in 2021, respectively. The incidence rate of class C decreased by 71.23% in 2020 and 58.76%in 2021, respectively. The incidence rates of intestinal infectious disease, respiratory infectious disease, blood infectious disease and sexually transmitted disease during 2020-2021 were lower than the average levels during 2017-2019, which decreased by 59.27%, 68.02% and 36.52% respectively in 2020, and decreased by 37.96%, 56.37% and 30.51% respectively in 2021. The incidence rates of HFMD in 2020 and 2021 were still highest during 2020-2021 (39.01/100000 and 75.87/100000). Conclusion: The implementation of COVID-19 prevention and control measures had influence on the incidence of notifiable infectious diseases with different transmission routes, especially the respiratory infectious diseases, but the influence on the rank of top five notifiable infectious diseases was not obvious.
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Objective: To investigate the prevalence of asymptomatic norovirus infections status in kitchen workers in schools, child care settings, and catering service units and other key places in Tongzhou district of Beijing from 2019 to 2021, and provide evidence for scientific prevention and control of norovirus infection. Methods: The simple random sampling method was used to select the kitchen workers, especially the kitchen workers preparing cold dish, from catering service units, schools, childcare settings, construction sites, hotels as study subjects, and their anal swabs or stool samples were collected for norovirus nucleic acid detection by fluorescence quantitative PCR. Descriptive method was used to analyze the asymptomatic norovirus infection status of the kitchen workers. Results: A total of 3880 samples were collected from 552 units, and 15 norovirus positive cases were detected, including 1 sample positive for GI and 14 samples positive for GII. The asymptomatic norovirus infection rate was 0.39% (15/3880), in which 0.30% (5/1656) in man, and 0.45% (10/2224) in women. No asymptomatic infections were detected in age groups < 18 years and > 60 years, and 2055 cases were detected in age group 19- years, with a positive rate of 0.34% (7/2055), and 1637 cases were detected in age group 46- years, with a positive rate of 0.49% (8/1637). In 2019 when no COVID-19 epidemic occurred, the asymptomatic norovirus infection rate was 1.00% (1/100), but the asymptomatic norovirus infection rate was 0.39% (11/2805)in 2020 and 0.31%(3/975)in 2021 in the context of COVID-19 epidemic. Conclusion: The asymptomatic norovirus infection rate in kitchen workers in key places in Tongzhou was similar to the average level in Beijing during the same period. In COVID-19 epidemic period, the asymptomatic norovirus infection rate was lower than that before the epidemic.
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Objective: To understand the awareness level towards coronavirus disease 2019(COVID-19) prevention and the willingness to receive COVID-19 vaccine among people living with HIV/AIDS, and to discuss the related factors. Methods: A questionnaire survey was conducted among people living with HIV/AIDS who visited the HIV clinic in the PLA General Hospital from June to December 2021.A general descriptive analysis, univariate and binary logistic regression analysis were performed to analyze data. Results: A total of 169 questionnaires were analyzed. Among them, 93.5%(158/169) would like to know more about COVID-19 related knowledge, 88.2%(149/169) were reminded to inject vaccine, 98.8%(167/169) would be far away from medium and high risk areas, 97.0%(164/169) would persuade others to follow the disease preventive requirements, 14.2%(24/169) thought that the propaganda was exaggerated, 30.8%(52/169) were worried about the safety of the vaccine, 80.5%(136/169) thought that they would feel relieved after the vaccination, and 98.2%(166/169) agreed that vaccination was the most effective way to fight against COVID-19. However, only 60.4%(102/169) were willing to receive COVID-19 vaccine. The major factors affecting vaccination intention were age and feeling safe after vaccination. Conclusions: People living with HIV/AIDS are more cautious about COVID-19 vaccination, therefore the coverage rate is relatively low.It is necessary for health providers to understand the specific situation of people living with HIV, and to enhance the heath education on the safety of COVID-19 vaccine especially among people with HIV/AIDS in order to improve the willingness to receive COVID-19 vaccine.
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Effectively blocking the transmission route of coronavirus and protecting the susceptible population play significant roles in the control of COVID-19 pandemic. Strengthening home-based medical observation is one of the key points in preventing the spread of SARS-CoV-2 virus in families and communities. Therefore, in order to meet the needs for COVID-19 prevention and control in Beijing, a group of experts organized by Beijing Association of Preventive Medicine developed the Guidelines for medical observation management of close contacts with COVID-19 cases Part 3: home-based medical observation(T/BPMA007.3-2020), which offers the specific provisions for close contacts of COVID-19 cases who need home-based medical observation as well as home environmental condition, prevention and control requirements, waste disposal, disinfection, community prevention and control work requirements, basic requirements for training and education and management guidelines.It provides standard support for home-based medical observation of close contacts with COVID-19 cases.
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Objective: To investigate the psychological characteristics of college students during the outbreak of coronavirus disease 2019 (COVID-19), so as to provide a basis for psychological intervention. Methods: From May 17, 2020 to Jun. 17, 2020, the adjusted psychological questionnaires for emergent events of public health (PQEEPH) was surveyed among the college students of Beijing Union University. The questionnaire included 5 dimensions:depression, neurasthenia, fear, obsessive-compulsive anxiety, and hypochondriasis. Four grades were scored according to the degree and frequency of emotional responses:0 means no symptoms, 1 means mild symptoms, 2 means moderate symptoms, and 3 means severe symptoms. Results: A total of 3 019 valid questionnaires were collected. During the COVID-19 epidemic, the emotional responses of college students, from the most serious to the least, were fear, neurasthenia, depression, obsessive-compulsive anxiety, and hypochondriasis, with the incidences being 87.7% (2 648/3 019), 44.8% (1 353/3 019), 37.4% (1 129/3 019), 17.3% (522/3 019), and 11.6% (350/3 019), respectively. The fear scores of female students were higher than those of male students (P < 0.001), the fear scores of college students from towns/suburbs were higher than those from rural and urban areas (both P < 0.017), the scores of depression, neurasthenia and obsessivecompulsive anxiety of college students with confirmed COVID-19 cases around them or their relatives participated in the epidemic prevention and control as medical staff or logistics support personnel were higher than those without such conditions (all P < 0.017), and the scores of depression, obsessive-compulsive anxiety and hypochondriasis of college students with suspected COVID-19 cases around them were higher than those without such condition (all P < 0.017). Females were more likely to have moderate to severe fear than males (odds ratio[OR]=1.53, 95% confidence interval[CI] 1.25-1.88, P < 0.001), those with confirmed or suspected COVID-19 cases around them were more likely to have moderate to severe fear than those without such conditions (OR=2.03, 95% CI 1.29-3.20, P=0.002), and those living in towns/suburbs were more likely to have moderate to severe fear than those living in rural and urban areas (OR=0.72, 95% CI 0.56-0.94, P=0.015;OR=0.78, 95% CI 0.63-0.97, P=0.025). Conclusion: COVID-19 epidemic has impact on the psychology of college students. It is necessary to pay attention to the mental health of college students and provide targeted psychological counseling for them.
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Objective: To investigate the quality of life (QOL) of coronavirus disease 2019(COVID-19) patients in the recovery stage of six months after discharge and to analyze the influence factors. Methods: Based on the COVID-19 case registration system whose establishment was led by Beijing University of Chinese Medicine Third Affiliated Hospital, 117 COVID-19 patients in the recovery stage hospitalized in designated hospitals of COVID-19 in Wuhan, Hubei Province from January 17th to March 17th, 2020 were taken as the research objects and were followed up for six months after discharge. The QOL of patients was investigated with the World Health Organization Quality of Life-BREF (WHOQOL-BREF) face to face. The score of the QOL of patients with different clinical characteristics was analyzed and compared. The relationship between different clinical characteristics and the total score of the QOL of patients was analyzed by Pearson correlation analysis. Statistically significant factors were included in the linear regression analysis and the linear correlation equation of the total score of the QOL was obtained. Results: The total score of the QOL of patients in the WHOQOL-BREF scale was 75.79 +or- 13.80 points, the self-evaluation of the QOL was 3.20 +or- 0.78 points, and the self-evaluation of health condition was 2.60 +or- 0.79 points. The total score of the QOL of female patients, patients with high sequelae grade, and patients with history of smoking was lower than that of male patients, patients with low sequelae grade, and patients without history of smoking. The Pearson correlation analysis showed that the typing of the acute stage of COVID-19, sequelae grade, gender, and history of smoking were related to the total score of the QOL of patients at six months after discharge. The linear regression analysis showed that sequelae grade was linearly correlated with the total score of the QOL of patients at six months after discharge. Linear correlation equation was Y=94.179-9.153X. Conclusions: At six months after discharge, COVID-19 patients in the recovery stage were generally dissatisfied with their QOL and health condition. Their overall QOL was relatively low. It was affected by factors such as gender, BMI, underlying diseases, and history of smoking. And the sequelae symptoms had the most significant impact.
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Objective: To understand the awereness and health needs of parents in regards to infectious diseases in kindergartens in Chengdu, and to provide a reference for carrying out targeted health education on infectious diseases. Methods: The parents of kindergarten children in Chenghua District of Chengdu was selected by convenient sampling, and a self-designed questionnaire was used. Results: The rate of awareness among parents regarding pediatric infectious diseases was 42.0%, among which the awareness rate of "treatment measures following a dog bite" was the highest (99.6%), and "the awareness rate of infectious disease classifications in China" was the lowest (26.7%). The awareness rate was related to family role, education level, occupation and income level (X2=10.81, 71.81, 93.78, 25.17, P < 0.05). The survey examined the demand for knowledge regarding pediatric infectious disease prevention and control, and revealed that parents primarily obtained such information from the school class group (85.5%). The most desirable way of obtaining relevant information was from information provided by professional institutions (96.6%), the infectious disease that parents most wanted to know about was the 2019 novel coronavirus (91.9%), and the most desirable time to acquire knowledge about infectious diseases depended on the seasonal arrangement of infectious diseases (67.5%). Conclusion: The awareness rate of parents about children's infectious diseases is in the middle level, and the channels for acquiring the knowledge about infectious diseases are relatively limited. Schools can carry out targeted health education in order to raise the awareness rate of parents of preschool children about children's infectious diseases.
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Since the outbreak of COVID-19, digital nomads, a group of people who work remotely while traveling, have been emerging as a hot research topic in the global academic community. With the rising number of digital nomads in China, several tourist destinations, such as Dali in Yunnan, and Anji in Zhejiang, have evolved into digital nomad destinations, and this trend is expanding. However, the concept of digital nomads remains relatively unexamined by China's academic community, as evidenced by the limited academic research and considerable lag of academic research behind industry practice. First, this paper establishes the conceptual foundations of digital nomads based on content analysis. It offers a detailed definition established through an exploration of the work, travel, and lifestyle perspectives of digital nomads. Six indicators have been identified to distinguish digital nomads from remote workers, business travelers, and working tourists, including location independence, mobility, work focus, work digitization, precarity, and travel frequency. Further, the characteristics (including the pursuit of freedom, uninterrupted travel, working while traveling, professional and informational literacy, and invasion and integration of the destination culture) and supporting systems (co-spaces, digital and technical support, and economic and social support) are discussed. Next, this paper investigated the origin and evolution of digital nomads through an analysis of the evolutionary paths of work style from nomadic worker to digital knowmad, and from knowledge worker to digital knowledge worker to digital knowmad, the evolution of leisure travel style from backpacker to flashpacker to flashpacker nomad and the evolution of lifestyle from nomad to global/neo-nomad to digital nomad. Finally, the current state of digital nomad research is surveyed, highlighting research themes, key theoretical frameworks, gaps in knowledge, and areas for future research. Insights into digital nomads are explored, including (1) the applicability of conceptual definitions of digital nomads at the operational level, (2) the practical validity of theoretical frameworks for digital nomad research, (3) the impact of digital nomads on the evolution of destinations, the urban-rural development, digital economic development, and the mechanisms involved, and (4) the emerging research on digital nomads in China with a focus on understanding the unique economic, social and cultural characteristics of digital nomads in China compared to other countries. Based on the insights shared in this paper, future research directions for digital nomads are envisaged. This paper establishes a baseline for the research on digital nomads to guide future scholarly attention toward digital nomad research and provide a basis for the development and practical application of relevant theories in the context of the digital economy.
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Objective: To study students' mental health status during epidemic of novel coronavirus pneumonia, and to explore the influence of mindfulness level and perceived social support on mental health. Methods: A total of 240 undergraduate nursing students were investigated with Depression Anxiety and Stress Scale, Five Facets Mindfulness Questionnaire, Perceived Social Support Scale and Pittsburgh Sleep Quality Index. SAS and Mplus were applied to describe the data and conduct mediation analysis. Results: About 18.8% of the participants were depressed and 27.9% were anxious, 13.3% were stressed, and 31.7% had problems of sleeping. The mindfulness level could directly affect sleep disorder (beta = - 0.242, P < 0.001), stress (beta = - 0.397, P < 0.001), anxiety (beta = - 0.350, P < 0.001)and depression(beta = - 0.484, P < 0.001), and could also indirectly affect sleep disorder (beta = - 0.171, P < 0.001), stress (beta = - 0.105, P = 0.029), anxiety (beta = - 0.102, P = 0.034) and depression (beta = - 0.180, P < 0.001) via the mediation role of perceived social support with the mediating effects accounted for 41.40%, 20.92%, 22.52% and 37.19%, respectively. Conclusions: Mindfulness level can improve the mental health of nursing undergraduates through direct action and understanding the intermediary role of social support. Nursing educators can consider integrating mindfulness decompression training into daily teaching, and give nursing undergraduates enough psychological and emotional support and encouragement to improve their mental health level.
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In order to estimate the transmission of COVID-19, the asymptomatic class is introduced to the SEIADR model, an improved SEIADR model is proposed to analyze the influence of wearing face masks on the final size and the basic reproduction number of COVID-19. To study the impact of face masks on the transmission of COVID-19, the population is divided into two groups;one group wearing face masks (including susceptible, exposed, infectious, asymptomatic, dead and recovered), and the other not wearing face masks (including susceptible, exposed, infectious, asymptomatic, dead and recovered). The group dynamic model is used to determine the basic reproduction number and the control reproduction number of the epidemic. Then the final size of disease is simulated based on data. Finally, the dynamic influence of face masks on epidemic transmission is simulated by numerical analysis. Data simulations show that without any intervention, the basic reproduction number is 1.35. If 50% of population wear face masks, the susceptibility and infectivity are reduced by 50% 9 then the control reproduction number will decreased to 0.39, and the final epidemic size Will reduce from 73.20% to 16.15%.
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Background: Novel coronavirus pneumonia (NCP) and osteoporotic vertebral compression fractures (OVCF) are the high incidences of diseases in the elderly. During the epidemic period, if not treated in time, the complications are high and the mortality is high. If we do not pay attention to infection prevention and control in pre-hospital emergency care, it will lead to the first time infection of medical staff and in-hospital cross infection in emergency outpatient receiving area. The correct consideration of both and the establishment of perfect pre-hospital emergency treatment and infection prevention and control synchronous strategy is an important premise to ensure the stable, orderly and safe medical treatment. Background: To explore the effect of synchronous implementation of pre-hospital emergency care, nursing and infection pre-vention and control for senile OVCF during the epidemic. In order to improve the efficiency of pre-hospital emergency care and prevent the spread of infection. Method: A total of 92 elderly patients with OVCF who received pre-hospital treatment in 18 hospitals in Zhangjiakou City during the epidemic prevention and control period from January 2020 to November 2022 and met the inclusion criteria were selected as research objects, including 24 males and 68 females, aged 65 - 82 (74.2 +or- 2.2) years. All patients were associated with concomitant injuries and underlying diseases. All patients in this group underwent predictive pre-hospital rescue and infection prevention and control procedures. Results: All the 92 elderly patients with OVCF received timely pre-hospital treatment during the epidemic period, and no aggravation occurred of the 92 patients, 35 were in the high risk area, 10 were in the medium risk area, and 47 were in the low risk area. Exclude OVCF for NCP Patients were treated according to the conventional diagnosis and treatment principles. Suspected and confirmed cases are transferred to designated surgical hospitals for treatment. All patients were followed up 3 months, 6 months and 12 months after treatment. There was no death rate, high satisfaction of pre-hospital first aid, high diagnostic accuracy, and good curative effect. None of the rescue personnel had any infection rate, and no hospital infection transmission and nosocomial cross infection occurred. Conclusion: It is the first step to safely treat patients and prevent cross infection to establish a perfect synchronous strategy of pre-hospital first aid and infection prevention and control.
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Objective: To compare the clinical manifestations, liver function, and antibody levels between Omicron variant infection patients vaccinated and not vaccinated with COVID-19 vaccine. Methods: Totally 430 convalescent COVID-19 patients infected with Omicron variant in Tianjin were selected, including 150 patients vaccinated with Corona Vaccine(Sinovac group), 185 patients vaccinated with BBIBP-CorV(Beijing biological group), 41 patients vaccinated with Ad5-nCoV vaccine(CanSino group), 16 patients vaccinated with Anhui Zhifei, Changchun Bio, Lanzhou Bio, Shandong Bio, other adenovirus vector vaccines or mixed vaccination(other group), and 38 unvaccinated patients(unvaccinated group). The clinical manifestations, liver function indexes [alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TB), albumin(ALB), total protein(TP), lactate dehydrogenase(LDH)], and antibody levels(IgG, IgM)were compared retrospectively. Results: There was no statistical difference in the sex composition ratio among groups(P > 0.05). The age of the Beijing biological group was significantly lower than that of other groups, and the proportion of time less than 3 months from the last vaccination to admission in the Beijing biological group and CanSino group was significantly higher than that in the Sinovac group and other groups(all P < 0.01). A total of 110 children aged less than 16 years were enrolled, including 7, 88, 0, 1 and 14 cases in the Sinovac group, Beijing biological group, CanSino group, other group, and unvaccinated group, respectively. There were 6 asymptomatic cases, 13 moderate cases, 91 mild cases and 0 severe case. There was no significant difference in the abnormal rate of ALT between Beijing biological group and unvaccinated group(P > 0.05), but the abnormal rates of ALT were higher in the Sinovac group and CanSino group than in the unvaccinated group and Beijing biological group(all P < 0.05). The abnormal rate of AST in the unvaccinated group was higher than that in other groups(P < 0.05). There were no significant differences in AST, TP or TB among the groups(all P > 0.05). The levels of ALT were higher in the Sinovac group and CanSino group than in Beijing biological Group and unvaccinated group, the level of ALB in the unvaccinated group was lower than that in the other groups, and the level of LDH in the Beijing biological group was higher than those in the Sinovac group and CanSino group(both P < 0.05). The IgG and IgM antibody levels of the unvaccinated group were significantly lower than those of the Sinovac group, Beijing biological group and CanSino group(all P < 0.05). Conclusions: Omicron variant infection patients vaccinated with BBIBP-CorV are younger and have a higher proportion of mild conditions, which can protect the liver function of patients to a certain extent. Patients vaccinated with different COVID-19 vaccines can produce higher levels of IgG and IgM antibodies than the unvaccinated patients.
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The Bohai Bay as a typical semi-enclosed bay in northern China with poor water exchange capacity and significant coastal urbanization, is greatly influenced by land-based inputs and human activities. As a class of pseudo-persistent organic pollutants, the spatial and temporal distribution of Pharmaceuticals and Personal Care Products (PPCPs) is particularly important to the ecological environment, and it will be imperfect to assess the ecological risk of PPCPs for the lack of systematic investigation of their distribution in different season. 14 typical PPCPs were selected to analyze the spatial and temporal distribution in the Bohai Bay by combining online solid-phase extraction (SPE) and HPLC-MS/MS techniques in this study, and their ecological risks to aquatic organisms were assessed by risk quotients (RQs) and concentration addition (CA) model. It was found that PPCPs widely presented in the Bohai Bay with significant differences of spatial and seasonal distribution. The concentrations of ∑PPCPs were higher in autumn than in summer. The distribution of individual pollutants also showed significant seasonal differences. The high values were mainly distributed in estuaries and near-shore outfalls. Mariculture activities in the northern part of the Bohai Bay made a greater contribution to the input of PPCPs. Caffeine, florfenicol, enrofloxacin and norfloxacin were the main pollutants in the Bohai Bay, with detection frequencies exceeding 80 %. The ecological risk of PPCPs to algae was significantly higher than that to invertebrates and fish. CA model indicated that the potential mixture risk of total PPCPs was not negligible, with 34 % and 88 % of stations having mixture risk in summer and autumn, respectively. The temporary stagnation of productive life caused by Covid-19 weakened the input of PPCPs to the Bohai Bay, reducing the cumulative effects of the pollutants. This study was the first full-coverage investigation of PPCPs in the Bohai Bay for different seasons, providing an important basis for the ecological risk assessment and pollution prevention of PPCPs in the bay. © 2022 Elsevier B.V.
ABSTRACT
This study aimed to evaluate the application and diagnostic efficacy of two different colloidal gold kits for the detection of 2019-nCoV immunoglobulin M antibody (anti-IgM) and immunoglobulin G antibody (anti-IgG) in Beijing, a low endemic area, and to guide the rational clinical application. The sera of 29 patients with confirmed novel coronavirus pneumonia (COVID-19) and 19 411 patients from the non-infected screening population were selected to evaluate the sensitivity, specificity and false-positive rate of the 2019-nCoV antibody test kits from Zhuhai Lizhu and Tangshan Innotek using colloidal gold immunochromatography. The sensitivity of Inotec 2019-nCoV was slightly higher than that of Lizhu 2019-nCoV, with a sensitivity of 58.62% and 55.17%, respectively;the specimen collection time of the all-negative group was significantly less than that of the antibody-positive group (P < 0.05);the false-positive rate of the two reagents in the low-prevalence area was 0.16%, and the false-positive rate of 2019-nCoV IgG was higher in Inotec than in Lizhu. The false positive rate for 2019-nCoV IgM was significantly higher than that for IgG for the same brand (Inotec ?2=14.756 09, P=0.000 0;Lizhu ?2=27.492 62, P=0.000). Conclusion The 2019-nCoV antibody test is rapid, simple and easy to perform, with high specificity, and can be used as a rapid screening indicator for new crowns;the specificity, correctness and negative predictive value of the two kits are good, and the application of the other kit for retesting when a positive result occurs can reduce the false positive rate of informing the clinic;the application and analysis of positive reports of new crown antibodies should be combined with the endemic area and clinical comprehensive judgment.